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Cat. No. | Product Name | ||
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L2610 | 神经递质受体化合物库 | 1513 compounds | |
1513 种与神经递质受体相关的化合物,用于高通量、高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T22277 |
BMS-P5
|
PAD | Chromatin/Epigenetic |
BMS-P5 是一种特异性具有口服活性的肽精氨酸二亚胺酶 4抑制剂。它可阻断多发性骨髓瘤诱导的 NET 形成,并延缓肿瘤进程。 | |||
T22277L |
BMS-P5 free base
|
PAD | Chromatin/Epigenetic |
BMS-P5 free base 是一种特异性,可口服的肽精氨酸二亚胺酶抑制剂,可阻断多发性骨髓瘤诱导的 NET 形成,并延缓肿瘤进程。 | |||
TP1496L |
p5 Ligand for Dnak and DnaJ acetate
p5 Ligand for Dnak and DnaJ acetate(209518-24-1 free base) |
HSP | Cytoskeletal Signaling; Metabolism |
p5 Ligand for Dnak and DnaJ acetate(209518-24-1 free base) 是一种九肽。它是 DnaK(大肠杆菌 Hsp70)和 DnaJ(大肠杆菌 Hsp40)的高亲和力配体。 | |||
T30072 | Aniline, p-(5-(p-methoxyphenoxy)pentyloxy)- | ||
Aniline, p-(5-(p-methoxyphenoxy)pentyloxy)- is a bioactive chemical. | |||
T30071 | Aniline, p-(5-(p-ethoxyphenoxy)pentyloxy)- | ||
Aniline, p-(5-(p-ethoxyphenoxy)pentyloxy)- is a bioactive chemical. | |||
T30073 |
Aniline, p-(5-(p-phenoxyphenoxy)pentyloxy)-
|
||
Aniline, p-(5-(p-phenoxyphenoxy)pentyloxy)- is a bioactive chemical. | |||
T30075 |
Aniline, p-(5-phenoxypentyloxy)-
|
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Aniline, p-(5-phenoxypentyloxy)- is a bioactive chemical. | |||
T10142L |
p-Ethynylphenylalanine hydrochloride
4-Ethynyl-L-phenylalanine HCL,p-Ethynylphenylalanine hydrochloride(278605-15-5 free base) |
Hydroxylase | Metabolism |
p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine HCL) 是一种高效的、可逆的、选择性的、竞争性的色氨酸羟化酶 (TPH) 抑制剂,其Ki=32.6 μM。 | |||
T15477 |
Hexaminolevulinate hydrochloride
Hexyl 5-aminolevulinate hydrochloride,5-Aminolevulinic acid hexyl ester hydrochloride,P-1206,5-氨基酮戊酸己酯盐酸盐 |
Others | Others |
Hexaminolevulinate hydrochloride (P-1206) 是一种被批准的、可用于膀胱镜检测乳头状膀胱癌的荧光剂。 | |||
T16421 |
p-MPPI hydrochloride
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
p-MPPI hydrochloride 是一种选择性的,具有高亲和力的5-HT1A 受体拮抗剂,能穿过血脑屏障,具有抗抑郁和抗焦虑样作用。 | |||
T30074 |
Aniline, p-(5-(p-tolyloxy)pentyloxy)-, hydrochloride
|
||
Aniline, p-(5-(p-tolyloxy)pentyloxy)-, hydrochloride is a bioactive chemical. | |||
T30405 |
Benzoic acid, p-(5-(p-aminophenoxy)pentyloxy)-, hydrochloride
|
||
Benzoic acid, p-(5-(p-aminophenoxy)pentyloxy)-, hydrochloride is a bioactive chemical. | |||
T30076 | Aniline, p-(5-phenylpentyloxy)-, methanesulfonate | ||
Aniline, p-(5-phenylpentyloxy)-, methanesulfonate is a bioactive chemical. | |||
T29309 |
1-Pentanol, 5-(p-aminophenoxy)-
|
||
1-Pentanol, 5-(p-aminophenoxy)- is a bioactive chemical. | |||
T35025 | Valeric acid, 5-(p-aminophenoxy)- | ||
Valeric acid, 5-(p-aminophenoxy)- is a bioactive chemical. | |||
T30342 | Benzamide, N-(5-(p-aminophenoxy)pentyl)-p-hydroxy- | ||
Benzamide, N-(5-(p-aminophenoxy)pentyl)-p-hydroxy- is a bioactive chemical. | |||
T30070 | Aniline, p-(5-(2-naphthyloxy)pentyloxy)- | ||
Aniline, p-(5-(2-naphthyloxy)pentyloxy)- is a bioactive chemical. | |||
T9229 |
Pim-1/2 kinase inhibitor 1
|
Pim | Chromatin/Epigenetic; JAK/STAT signaling |
Pim-1/2 kinase inhibitor 1 是一种具有口服活性的 Pim-1/2 激酶抑制剂。Pim-1/2 kinase inhibitor 1 能阻断 Pim 激酶磷酸化肽的能力,并且抑制4E-BP1和p27Kip1的Pim 蛋白激酶定向磷酸化。Pim-1/2 kinase inhibitor 1 可用于癌症,尤其是前列腺癌的研究。 | |||
T31947 | Glutarimide, N-(5-(p-aminophenoxy)pentyl)- | ||
Glutarimide, N-(5-(p-aminophenoxy)pentyl)- is a bioactive chemical. | |||
T29560 | Acetamide, N-(5-(p-aminophenoxy)pentyl)- | ||
Acetamide, N-(5-(p-aminophenoxy)pentyl)- is a bioactive chemical. | |||
T31848 |
Formamide, N-(5-(p-aminophenoxy)pentyl)-
|
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Formamide, N-(5-(p-aminophenoxy)pentyl)- is a bioactive chemical. | |||
T33665 |
Nicotinamide, N-(5-(p-aminophenoxy)pentyl)-
|
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Nicotinamide, N-(5-(p-aminophenoxy)pentyl)- is a bioactive chemical. | |||
T31961 |
Glycolanilide, 4'-(5-(p-aminophenoxy)pentyloxy)-
|
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Glycolanilide, 4'-(5-(p-aminophenoxy)pentyloxy)- is a bioactive chemical. | |||
T18923 |
BCIP
5-溴-4-氯-3-吲哚基磷酸酯对甲苯胺盐,BCIP p-toluidine salt,X-phosphate p-toluidine salt |
Others | Others |
BCIP (BCIP p-toluidine salt) 是一种显色底物,可用于碱性磷酸酶活性的比色法检测。 | |||
T30350 | Benzanilide, N-(5-(p-aminophenoxy)pentyl)- | ||
Benzanilide, N-(5-(p-aminophenoxy)pentyl)- is a bioactive chemical. | |||
T31692 | Ethanol, 2-(5-(p-aminophenoxy)pentyloxy)- | ||
Ethanol, 2-(5-(p-aminophenoxy)pentyloxy)- is a bioactive chemical. | |||
T34735 | Succinimide, N-(5-(p-aminophenoxy)pentyl)- | ||
Succinimide, N-(5-(p-aminophenoxy)pentyl)- is a bioactive chemical. | |||
T32223 |
Isonicotinamide, N-(5-(p-aminophenoxy)pentyl)-
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Isonicotinamide, N-(5-(p-aminophenoxy)pentyl)- is a bioactive chemical. | |||
T29586 | Acetophenone, 4'-(5-(p-aminophenoxy)pentyloxy)- | ||
Acetophenone, 4'-(5-(p-aminophenoxy)pentyloxy)- is a bioactive chemical. | |||
T34203 |
Pyridine, 2-(5-(p-aminophenoxy)pentyloxy)-
|
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Pyridine, 2-(5-(p-aminophenoxy)pentyloxy)- is a bioactive chemical. | |||
T33167 | Maleimide, N-(5-(p-aminophenoxy)pentyl)- | ||
Maleimide, N-(5-(p-aminophenoxy)pentyl)- is a Drug / Therapeutic Agent. | |||
T33251 | m-Dioxan-5-amine, 2-(p-chlorophenyl)-5-methyl- | ||
m-Dioxan-5-amine, 2-(p-chlorophenyl)-5-methyl- is a bioactive chemical. | |||
T33250 |
m-Dioxan-5-amine, 2-(p-chlorophenyl)-5-ethyl-
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m-Dioxan-5-amine, 2-(p-chlorophenyl)-5-ethyl- is a bioactive chemical. | |||
T33177 | m-Anisamide, N-(5-(p-aminophenoxy)pentyl)- | ||
m-Anisamide, N-(5-(p-aminophenoxy)pentyl)- is a bioactive chemical. | |||
T33769 | o-Anisamide, N-(5-(p-aminophenoxy)pentyl)- | ||
o-Anisamide, N-(5-(p-aminophenoxy)pentyl)- is a bioactive chemical. | |||
T29349 |
2-Furamide, N-(5-(p-aminophenoxy)pentyl)-
|
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2-Furamide, N-(5-(p-aminophenoxy)pentyl)- is a bioactive chemical. | |||
T35016 | Valeramide, N-(5-(p-aminophenoxy)pentyl)-5-phenyl- | ||
Valeramide, N-(5-(p-aminophenoxy)pentyl)-5-phenyl- is a bioactive chemical. | |||
T33249 | m-Dioxan-5-amine, 2-(p-chlorophenyl)- | ||
m-Dioxan-5-amine, 2-(p-chlorophenyl)- is a bioactive chemical. | |||
T10066 |
2',5'-Dideoxyadenosine
|
Adenylyl cyclase; Adrenergic Receptor; AChR | GPCR/G Protein; Neuroscience |
2',5'-Dideoxyadenosine 是一种非竞争性腺苷酸环化酶抑制剂,通过结合 P 位点,IC50为 3 µM。它是核苷类似物,在心脏中发挥强大的抗肾上腺素作用。 | |||
TQ0311 |
GSK163090
|
Dopamine Receptor; 5-HT Receptor | GPCR/G Protein; Neuroscience |
GSK163090 是选择性和具有口服活性的5-HT1A/1B/1D 受体拮抗剂,pKi 值分别为 9.4、8.5 和 9.7。它抑制血清素再摄取转运蛋白的功能活性,pKi 值为 6.1,具有抗抑郁和抗焦虑活性。 | |||
T33189 | m-Anisidine, 4-((5-p-tolylpentyl)oxy)- | ||
m-Anisidine, 4-((5-p-tolylpentyl)oxy)- is a Drug / Therapeutic Agent. | |||
T3230 |
NLRP3-IN-2
5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide,4-[2-(5-氯-2-甲氧基苯甲酰氨基)乙基]苯磺酰胺,NLRP3 Inflammasome Inhibitor I |
NOD-like Receptor (NLR); NOD | Immunology/Inflammation; NF-κB |
NLRP3-IN-2 (5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide) 是一种能够合成格列本脲的中间物,对心肌细胞中NLRP3炎症小体的形成具有抑制作用,在小鼠心肌缺血/再灌注后限制梗死面积,且对代谢无影响。 | |||
T13383 |
Zamicastat
BIA 5-1058 |
BCRP; Hydroxylase; P-gp | Membrane transporter/Ion channel; Metabolism; Neuroscience |
Zamicastat (BIA 5-1058) 是多巴胺 β-羟化酶 (DBH) 抑制剂,可透过血脑屏障引起中枢和周边效应,具有降血压作用。它也是一种浓度依赖性的双重 P-gp 和 BCRP 抑制剂,IC50值分别为 73.8 和 17.0 μM。 | |||
T30341 | Benzamide, N-(5-(p-aminophenoxy)pentyl)-N-methyl- | ||
Benzamide, N-(5-(p-aminophenoxy)pentyl)-N-methyl- is a bioactive chemical. | |||
T33184 |
m-Anisidine, 4-((5-(p-methoxyphenyl)pentyl)oxy)-
|
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m-Anisidine, 4-((5-(p-methoxyphenyl)pentyl)oxy)- is a Drug / Therapeutic Agent. | |||
T29565 | Acetamide, N-(5-(p-aminophenoxy)pentyl)-2-phenyl- | ||
Acetamide, N-(5-(p-aminophenoxy)pentyl)-2-phenyl- is a bioactive chemical. | |||
T30347 |
Benzamide, N,N-bis(5-(p-aminophenoxy)pentyl)-
|
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Benzamide, N,N-bis(5-(p-aminophenoxy)pentyl)- is a bioactive chemical. | |||
T29376 | 2-Thiophenecarboxamide, N-(5-(p-aminophenoxy)pentyl)- | ||
2-Thiophenecarboxamide, N-(5-(p-aminophenoxy)pentyl)- is a bioactive chemical. | |||
T33185 | m-Anisidine, 4-((5-(p-nitrophenyl)pentyl)oxy)- | ||
m-Anisidine, 4-((5-(p-nitrophenyl)pentyl)oxy)- is a bioactive chemical. | |||
T29563 | Acetamide, N-(5-(p-aminophenoxy)pentyl)-2-cyano- | ||
Acetamide, N-(5-(p-aminophenoxy)pentyl)-2-cyano- is a Drug / Therapeutic Agent. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4685 |
INOSINIC ACID
Inosine 5′-monophosphate,IMP,5'-肌苷酸,I-5'-P |
Endogenous Metabolite | Metabolism |
Inosinic acid (IMP) 是内源性代谢产物。 | |||
T4447 |
S-(5'-Adenosyl)-L-methionine tosylate
S-腺苷蛋氨酸对甲苯磺酸盐,SAMe,S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt |
Others | Others |
S-(5'-Adenosyl)-L-methionine tosylate (SAMe) 是一种普遍存在的甲基供体,参与多种生物反应,包括由 DNA 和蛋白质甲基转移酶介导的反应。它可改善抑郁、与骨关节炎和纤维肌痛相关的疼痛以及肝毒性。 | |||
T3578 |
Pyridoxal phosphate
PLP,PAL-P,磷酸吡哆醛,pyridoxal 5'-phosphate,Pyridoxyl phosphate,Pyridoxal 5′-phosphate,Vitamin B6 phosphate |
Reverse Transcriptase; Endogenous Metabolite | Metabolism; Microbiology/Virology |
Pyridoxal phosphate (Vitamin B6 phosphate) 是维生素 B6 的活性形式,可抑制逆转录酶活性,用于研究迟发性运动障碍症。 | |||
T3740 |
Isovanillin
3-羟基-4-甲氧基苯甲醛,3-Hydroxy-p-anisaldehyde,3-Hydroxy-4-methoxybenzaldehyde,5-Formylguaiacol |
Others | Others |
Isovanillin (5-Formylguaiacol) 是一种醛氧化酶抑制剂,具有解痉挛和止泻活性。 | |||
T3915 |
Ginsenoside Ro
人参皂苷Ro,Chikusetsusaponin 5,Polysciasaponin P3,人参皂苷 Ro,Chikusetsusaponin V |
Calcium Channel; Reductase; Prostaglandin Receptor | Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism |
Ginsenoside Ro (Chikusetsusaponin V) 能降低 TXA2产量,较弱降低 COX-1 和 TXAS 活性,具有 Ca2+拮抗剂的抗血小板作用,IC50为 155 μM。 | |||
T81506 |
Petunidin-3-O-(6-O-p-coumaryl)-5-O-diglucoside
|
||
Petunidin-3-O-(6-O-p-coumaryl)-5-O-diglucoside 是葡萄中可分离提取的天然产物。 | |||
TN2030 |
P-Hydroxyphenethyl trans-ferulate
反式-阿魏酸对羟基苯乙酯 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
p-Hydroxyphenethyl trans-ferulate 具有抗高血糖 (酵母α-葡萄糖苷酶,IC5019.24 ± 1.73 µmol L-1),抗氧化,抗炎活性,也具有抗癌特性和血清素能特性。 | |||
T3868 |
Agnuside
牡荆油,穗花牡荆苷,chasteberry oil |
COX; Prostaglandin Receptor; P-gp | GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience |
Agnuside (chasteberry oil) 是从黄荆中分离得到的一种天然产物,可下调炎性介质PGE2和LTB4,减少细胞因子的表达,具有抗关节炎活性。 | |||
TCS2070 |
Homogentisic acid
高龙胆酸,2,5-dihydroxyphenylacetic acid,Homogentisinic Acid,Melanic acid |
Antioxidant; Endogenous Metabolite | Metabolism; oxidation-reduction |
Homogentisic acid (2,5-dihydroxyphenylacetic acid) 是一种尿液和血清代谢物中的特定代谢物,可用于尿黑酸尿症的诊断。 | |||
T2S2169 |
Naringenin trimethyl ether
柚皮素三甲醚,5,7,4'-Trimethoxyflavanone |
Others | Others |
Naringenin trimethyl ether (5,7,4'-Trimethoxyflavanone) 是四季米仔兰枝、叶的成分。它具有明显的杀螺作用,对 P. canaliculata 作用的 LC50值为 3.9 μg/ mL。 | |||
T4S0498 |
Glaucocalyxin A
蓝萼甲素,Wangzaozin B,Leukamenin F |
Apoptosis; Akt; Caspase; PI3K | Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Glaucocalyxin A (Leukamenin F) 是来自日本黑纹病菌的一种对映型月桂基二萜,具有抗肿瘤作用。它通过调节PI3K/Akt 信号通路抑制 GLI1 的核易位,诱导骨肉瘤凋亡。 | |||
T83606 |
(-)-β-Peltatin-5-O-beta-D-glucopyranoside
|
||
(-)-β-Peltatin-5-O-beta-D-glucopyranoside为自P. peltatum L中分离出的活性化合物。 | |||
TN2726 |
Jatrophane 5
|
P-gp | Membrane transporter/Ion channel; Neuroscience |
Jatrophane 5 demonstrates the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR). | |||
TN3283 | 8alpha-Hydroxylabda-13(16),14-dien-19-yl p-hydroxycinnamate | Others | Others |
8alpha-Hydroxylabda-13(16),14-dien-19-yl p-hydroxycinnamate 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN3283,CAS号为 117254-98-5。 | |||
TN5487 |
3'',4''-Di-O-p-coumaroylquercitrin
Quercetin 3-O-(3”,4”-di-E-p-coumaroyl)-α-L-rhamnopyranoside,3'',4''-二-O-对香豆酰槲皮苷 |
||
3'',4''-Di-O-p-coumaroylquercitrin 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5487,CAS号为 437615-43-5。 | |||
TN5842 |
1,6,2',3',6'-O-Pentaacetyl-3-O-trans-p-coumaroylsucrose
|
||
1,6,2',3',6'-O-Pentaacetyl-3-O-trans-p-coumaroylsucrose 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5842,CAS号为 138213-63-5。 | |||
T40859 |
5-Hydroxy-8-methoxypsoralen
5-Hydroxyxanthotoxin,5-Hydroxy-8-methoxypsoralen |
||
5-Hydroxy-8-methoxypsoralen (5-Hydroxyxanthotoxin) is a metabolite derived from Xanthotoxin, which acts as a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450). It is employed as an agent for the treatment of psoriasis, eczema, vitiligo, and certain cutaneous Lymphomas, in combination with phototherapy involving exposure to sunlight. | |||
T75676 | Orotidine 5′-monophosphate trisodium | ||
Orotidine 5'-monophosphate trisodium 是一种嘧啶核苷酸。Orotidine 5'-monophosphate trisodium 是通过从头合成途径合成的,用于在大量微生物中合成 DNA,包括 M. tuberculosis、S. cerevisiae、S. typhimurium 和 P. falciparum 等等。乳清酸磷酸核糖基转移酶 (OPRT) 以磷酸核糖焦磷酸 (PRPP) 和乳清酸 (OA) 作为底物催化合成 Orotidine 5'-monophosphate trisodium[1] | |||
TN5133 | 3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone | HIV Protease; Topoisomerase | DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome |
5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it shows considerably activity against HIV-1 reverse transcriptase. It exhibits cytotoxic activity against P-388 cell lines, it can inhibit DNA topoisomerase IIα activity, which may be responsible for the observed cytotoxicity. | |||
T37690 |
Phenylpyropene A
|
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Phenylpyropene A is a fungal metabolite originally isolated from P. griseofulvum that has enzyme inhibitory and insecticidal activities.1,2,3 It inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 0.8 μM).1 Phenylpyropene A inhibits diacylglycerol acyltransferase (DGAT) in rat liver microsomes (IC50 = 78.7 μM). It induces mortality in 100% of M. persicae when used at a concentration of 5 ppm.3 |1. Kwon, O.E., Rho, M.C., Song, H.Y., et al. Phenylpyropene A and B, new inhibitors of ... | |||
T36179 |
Aspulvinone O
|
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Aspulvinone O is a fungal metabolite that has been found in P. variotti and has antioxidant and anticancer activities.1,2 It scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in a cell-free assay (IC50 = 11.6 μM).1 Aspulvinone O inhibits aspartate transaminase 1 (GOT1; Kd = 3.32 μM) and is cytotoxic to PANC-1, AsPC-1, and SW1990 pancreatic cancer cells (IC50s = 20.54-26.8 μM).2 It reduces the oxygen consumption rate (OCR) and induces apoptosis in SW1990 cells. Aspulvinone O (2.5 and 5 mg/kg) redu... | |||
T37810 |
6',7'-Epoxybergamottin
|
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6'7'-Epoxybergamottin is a furanocoumarin found in grapefruit. It is a potent inhibitor of the cytochrome P450 (CYP) isoform CYP3A4 with an IC50 value of 0.30 ppm in a cell-free assay, 0.33 μM in HL7 human liver cells, and 0.22 μM in S9 human intestine cells. It has been studied in the context of drug interactions with grapefruit constituents. It is found in grapefruit juice at concentrations of 0.1-7.4 μM and inhibits the transport of talinolol , a permeability glycoprotein (P-gp/ABCB1) transpo... | |||
T37911 |
cis-Resveratrol
顺式白藜芦醇,(Z)-Resveratrol |
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Resveratrol is a potent phenolic antioxidant found in grapes, red wine, and various berries that also has antiproliferative and anti-inflammatory activity. cis-Resveratrol is the double bond isomer of trans-resveratrol, the more often studied and naturally abundant of the two resveratrol isomers. cis-Resveratrol exhibits antioxidant activity in the &#181M range similar to that observed with trans-resveratrol. It blocks production of reactive oxygen species (ROS) by inhibition of NAD(P)H oxidase ... | |||
T35750 |
Trypacidin
|
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Trypacidin is a fungal metabolite originally isolated fromA. fumigatus.1It is active againstB. subtilisandM. bovis(MICs = 12.5 and 1.25 μg/ml, respectively), as well asT. cruziandT. gondii(MICs = 5-10 and 10-20 μg/ml, respectively).1,2It reduces viability and induces lysis of A549 human lung cancer cells (IC50s = 7.4 μM for both).3Trypacidin increases survival in a mouse model ofT. gondiiinfection when administered in six doses of 12.5 mg/kg each.1 1.Balan, J., Ebringer, L., Nemec, P., et al.Ant... | |||
T35624 | Ajoene | ||
Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs = 5-160 &#181g/ml) and Gram-negative bacteria (MICs = 136-200 &#181g/ml), as well as yeasts (MICs = 10-20 &#181g/ml).1Ajoene is cytotoxic to mouse melanoma cells (IC50= 18 &#181M), as well as human colon, lung, mammary, and pancreatic cancer cells (IC50s = 7-41 &#181M).2It reduces... | |||
T38330 |
Collinin
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Collinin is a coumarin that has been found in Z. schinifolium and has diverse biological activities.1,2,3,4 It is active against drug-susceptible and -resistant strains of M. tuberculosis (MIC50s = 3.13-6.25 μg/ml).1 Collinin inhibits LPS-induced nitric oxide (NO) production (IC50 = 5.9 μM) and reduces COX-2 protein levels in RAW 264.7 cells.2 It completely inhibits aggregation of isolated rabbit platelets induced by arachidonic acid , collagen, or platelet activating factor (PAF) when used at a... |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-05518 |
Der p 5 Protein, Dermatophagoides pteronyssinus, Recombinant (His)
mite allergen Der p 5,DERP5 |
Dermatophagoides pteronyssinus | E. coli |
Der p 5 Protein, Dermatophagoides pteronyssinus, Recombinant (His) is expressed in E. coli with His tag. The predicted molecular weight is 16.6 kDa. Accession number: A0A6P6Y2A6 | |||
TMPJ-01145 |
ABCB5 Protein, Human, Recombinant (Trx)
ABCB5 P-gp,ATP-binding c... |
Human | E. coli |
ATP-binding cassette sub-family B member 5(ABCB5) is a plasma membrane-spanning protein. ABCB5 is principally expressed in physiological skin and human malignant melanoma. ABCB5 has been suggested to regulate skin progenitor cell fusion and mediate chemotherapeutic drug resistance in stem-like tumor cell subpopulations in human malignant melanoma. It is commonly over-expressed on circulating melanoma tumour cells. Furthermore, the ABCB5+ melanoma- initiating cells were demonstrated to express FL... | |||
TMPJ-00978 |
PIP4K2A Protein, Human, Recombinant (His)
Diphosphoinositide kinase 2-α,Ptd... |
Human | Human Cells |
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP4K2A) is a member of the phosphatidylinositol-4-phosphate 5-kinase family. It contains 1 PIPK domain and is expressed ubiquitously, with high levels in the brain. It catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). It may exert its function by regulating the levels of PtdIns5P, which functions in the... | |||
TMPY-06016 |
Phl p 5 Protein, Phleum pratense, Recombinant
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Phleum pratense | E. coli |
Phl p 5 Protein, Phleum pratense, Recombinant is expressed in E. coli. The predicted molecular weight is 28.7 kDa. Accession number: Q40960-1 | |||
TMPY-06149 |
Phl p 5 Protein, Phleum pratense, Recombinant (His)
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Phleum pratense | HEK293 |
Phl p 5 Protein, Phleum pratense, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 30.9 kDa. Accession number: Q40960-1 | |||
TMPJ-01124 |
PDIA6 Protein, Human, Recombinant (His)
Thioredoxin Domain-Containing Protein 7,P<... |
Human | Human Cells |
Protein Disulfide-Isomerase A6 (PDIA6) is a 48.5kDa protein that belongs to the protein disulfide isomerase family (PDI). PDIA6 is an enzyme in the endoplasmic reticulum in eukaryotes which catalyzes the formation and breakage of disulfide bonds between cysteine residues within proteins as they fold. The PDIA6 expressed in platelets, its functions as a chaperone that inhibits aggregation of misfolded proteins. PDIA6 is part a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA... | |||
TMPH-03093 |
Phl p 5a Protein, Phleum pratense, Recombinant (His & SUMO)
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Phleum pratense | E. coli |
Phl p 5a Protein, Phleum pratense, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPH-01982 |
RPS10P5 Protein, Human, Recombinant (His & SUMO)
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Human | E. coli |
RPS10P5 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPH-03094 |
Phl p 5b Protein, Phleum pratense, Recombinant (His & SUMO)
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Phleum pratense | E. coli |
Has ribonuclease activity. May be involved in host-pathogen interactions. | |||
TMPH-00782 |
OMP P5 Protein, Haemophilus influenzae, Recombinant (His & Myc & SUMO)
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Haemophilus influenzae | E. coli |
Acts as a fimbriae subunit, allowing adhesion to host cells.; With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows down solute passage. | |||
TMPH-02410 |
Lol p 5a Protein, Lolium perenne, Recombinant (His & Myc & SUMO)
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Lolium perenne | E. coli |
Lol p 5a Protein, Lolium perenne, Recombinant (His & Myc & SUMO) is expressed in E. coli with N-terminal 10xHis-SUMO tag and C-terminal Myc tag. The predicted molecular weight is 48.4 kDa. Accession number: Q40240 | |||
TMPJ-01323 |
NTAL Protein, Human, Recombinant (His)
Williams-Beuren Syndrome Chromosomal Region 5 P... |
Human | Human Cells |
Linker for Activation of T-Cells Family Member 2 (LAT2) is a single-pass type III membrane protein. LAT2 is highly expressed in the spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. LAT2 is involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. It may also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. ... | |||
TMPJ-01390 |
MINPP1 Protein, Human, Recombinant (His)
3,4,5)-Tetrakisphosphate 3-P<... |
Human | Human Cells |
Multiple Inositol Polyphosphate Phosphatase 1/MINPP1 is an enzyme that removes 3-phosphate from inositol phosphate substrates. MINPP1 also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate. MINPP1 is synthesized as a 487 amino acid precursor that contains an 30 amino acid signal peptide and a 457 amino aicd mature chain. MINPP1 is widely expressed with the highest levels found in kidney, liver and placenta. It acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and re... | |||
TMPY-01904 |
Influenza A H5N1 (A/Duck/Hong Kong/p46/97) Hemagglutinin/HA Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H5N1 | HEK293 |
The influenza viral Hemagglutinin (HA) protein is a homotrimer with a receptor binding pocket on the globular head of each monomer.HA has at least 18 different antigens. These subtypes are named H1 through H18.HA has two functions. Firstly, it allows the recognition of target vertebrate cells, accomplished through the binding to these cells' sialic acid-containing receptors. Secondly, once bound it facilitates the entry of the viral genome into the target cells by causing the fusion of the host ... | |||
TMPY-01903 |
Influenza A H5N1 (A/Duck/Hong Kong/p46/97) Hemagglutinin/HA1 Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H5N1 | HEK293 |
The influenza viral Hemagglutinin (HA) protein is a homotrimer with a receptor binding pocket on the globular head of each monomer.HA has at least 18 different antigens. These subtypes are named H1 through H18.HA has two functions. Firstly, it allows the recognition of target vertebrate cells, accomplished through the binding to these cells' sialic acid-containing receptors. Secondly, once bound it facilitates the entry of the viral genome into the target cells by causing the fusion of the host ... | |||
TMPY-05308 |
CD45 Protein, Human, Recombinant (aa 1-529, His)
GP180,B220,L-CA,protein tyrosine p |
Human | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins d... | |||
TMPH-02549 |
FHIT Protein, Mouse, Recombinant (His)
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Mouse | E. coli |
Possesses dinucleoside triphosphate hydrolase activity. Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Exhibits adenylylsulfatase activity, hydrolyzing adenosine 5'-phosphosulfate to yield AMP and sulfate. Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monop... | |||
TMPY-06739 |
Pol d 5 Protein, Mediterranean paper wasp, Recombinant
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Mediterranean paper wasp | P. pastoris |
Pol d 5 Protein, Mediterranean paper wasp, Recombinant is expressed in P. pastoris. The predicted molecular weight is 20 kDa. | |||
TMPH-00590 |
GlmU Protein, E. coli, Recombinant (His & Myc)
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E. coli | E. coli |
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain. | |||
TMPH-01858 |
PIP4K2B Protein, Human, Recombinant (His)
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Human | E. coli |
Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration. Its GTP-sensing activity is critical for metabolic adaptation. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conver... | |||
TMPJ-01185 |
SULT1C4 Protein, Human, Recombinant (His)
SULT1C4,Sulfotransferase,hCG_27301,SULT1C2 |
Human | E. coli |
Human Sulfotransferase (SULT1C4) is an enzyme that in humans is encoded by the SULT1C4 gene, belongs to the sulfotransferase 1 family. SULT1C4 is expressed at high levels in fetal lung and kidney and at low levels in fetal heart, adult kidney, ovary and spinal chord. Sulfotransferase utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. It shows activity towards p-nitrophenol and N-hy... | |||
TMPY-02418 |
kynureninase/KYNU Protein, Mouse, Recombinant (His)
kynureninase,4432411A05Rik |
Mouse | Baculovirus-Insect Cells |
KYNU (Kynureninase) is a Protein Coding gene. KYNU is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Genetic studies in the mouse and the human suggest that kynureninase activity may influence blood pressure and renal function. The gene coding kynureninase (KYNU) is also located on chromosome band 2q14-q23, where a linkage peak for essential hypertension w... | |||
TMPY-02479 |
kynureninase/KYNU Protein, Human, Recombinant (His)
KYNUU,kynureninase |
Human | Baculovirus-Insect Cells |
KYNU (Kynureninase) is a Protein Coding gene. KYNU is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Genetic studies in the mouse and the human suggest that kynureninase activity may influence blood pressure and renal function. The gene coding kynureninase (KYNU) is also located on chromosome band 2q14-q23, where a linkage peak for essential hypertension w... | |||
TMPY-02948 |
SULT1A3 Protein, Human, Recombinant (His)
M-PST,HAST,SULT1A3,ST1A3/ST1A4,HAST3,SULT1A4,TL- |
Human | E. coli |
SULT1A3 belongs to the sulfotransferase 1 family. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. They are different in their tissue distributions and substrate specificities while their gene structure (number and length of exons) is similar. SULT1A3 gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16; this gene and SULT1A4 ar... | |||
TMPY-01816 |
Pentraxin 3 Protein, Human, Recombinant (His)
TNFAIP5,pentraxin 3,PTX3... |
Human | HEK293 |
Pentraxin-related protein PTX3, also known as Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein, TSG-14, PTX3 and TNFAIP5, is a secreted protein that contains one pentaxin domain. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. Pentraxins are a family of evolutionarily conserved multifunctional pattern-recognition proteins characterized by a cycl... | |||
TMPY-02155 |
Prostatic Acid Phosphatase Protein, Human, Recombinant (His)
5'-NT,acid phosphatase, p |
Human | HEK293 |
Prostatic acid phosphatase (PAP, or ACPP), also known as prostatic specific acid phosphatase (PSAP), is an enzyme produced by the prostate. As a non-specific phosphomonoesterase, Prostatic acid phosphatase is synthesized and secreted into seminal plasma under androgenic control. The enzyme is a dimer of molecular weight around 100 kDa. Prostatic acid phosphatase is a clinically important protein for its relevance as a biomarker of prostate carcinoma. Furthermore, it has a potential role in ferti... | |||
TMPY-02672 |
Prostatic Acid Phosphatase Protein, Mouse, Recombinant (His)
5'-NT,9.104100899-104272570.1,P |
Mouse | HEK293 |
Prostatic acid phosphatase (PAP, or ACPP), also known as prostatic specific acid phosphatase (PSAP), is an enzyme produced by the prostate. As a non-specific phosphomonoesterase, Prostatic acid phosphatase is synthesized and secreted into seminal plasma under androgenic control. The enzyme is a dimer of molecular weight around 100 kDa. Prostatic acid phosphatase is a clinically important protein for its relevance as a biomarker of prostate carcinoma. Furthermore, it has a potential role in ferti... | |||
TMPH-03114 |
ITGB1 Protein, Pig, Recombinant (His & Myc)
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Sus scrofa (Pig) | E. coli |
Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibr... | |||
TMPY-05387 |
SLAMF7 Protein, Human, Recombinant (hFc)
SLAM family member 7,19A,SLAM7,CS1,CD319,CRACC |
Human | HEK293 |
SLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruit signaling lymphocyte activation molecule... | |||
TMPY-04318 |
GRIK2 Protein, Human, Recombinant (hFc)
GLUR6,EAA4,MRT6,GLR6,glutamate receptor, ionotro |
Human | HEK293 |
GRIK2 (Glutamate Ionotropic Receptor Kainate Type Subunit 2, also known as GluR6) is a Protein Coding gene. The GRIK2 (one of the kainate receptors) gene resides in a genetic linkage region (6q21) associated with bipolar disorder (BPD). The gene coding for GRIK2 has been suggested as a candidate gene for autism based on its localization in the autism-specific region on chromosome 6q21 and the involvement of receptor protein in cognitive functions like learning and memory. GRIK2 belongs to the gl... | |||
TMPJ-00854 |
ETS1 Protein, Human, Recombinant (His)
V-ets Erythroblastosis Virus E26 Oncogene Homolog 1 (Avian),... |
Human | E. coli |
ETS1 Protein (ETS1) is a nuclear protein that belongs to the ETS family. Members of this family recognize the core consensus DNA sequence GGAA/T in target genes. Proteins function either as transcriptional activators or repressors of numerous genes. They are involved in stem cell development, cell senescence and death, and tumorigenesis. ETS1 is a transcription factor, containing one ETS DNA-binding domain and one PNT (pointed) domain. it has been shown to interact with TTRAP, UBE2I and Death As... | |||
TMPY-05547 |
SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated
CS1,SLAM7,CD319,SLAM family member 7,CRACC,19A |
Human | HEK293 |
SLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruit signaling lymphocyte activation molecule... | |||
TMPY-05498 |
SR-BI/SCARB1 Protein, Human, Recombinant (hFc)
HDLQTL6,SR-BI,SRB1,CD36L1,CLA-1,CLA1,scavenger recep |
Human | HEK293 |
Scavenger receptor class B, member 1 (SCARB1), also known as CD36L1, is a member of the scavenger receptor family. SCARB1 is expressed primarily in liver and non placental steroidogenic tissues, and predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane. SCARB1 is proposed as a receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells, and is involved in a wide variety of physilogica... | |||
TMPK-01357 |
SIRP alpha V5 Protein, Human, Recombinant (His & Avi)
MFR,PTPNS1,P84,BIT,MYD-1,MYD1,SH<... |
Human | HEK293 |
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal. | |||
TMPK-01363 |
SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated
SIRP alpha,MFR,PTPNS1,SI... |
Human | HEK293 |
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. |